One PSX

No One Can Stop Mr. Domino is a puzzle-based action game with a dash of strategy thrown in for good measure. Taking on the role of either Mr. or Miss Domino (cosmetic differences aside, they're exactly the same), players waddle their way through six timed stages set within suburbia, dropping dominoes while moving along. Each stage is structured within a closed loop, requiring players to first drop dominoes and then knock into them on subsequent laps, with the ultimate goal of hitting certain objects or triggering specific switches. The screen scrolls continuously, requiring players to quickly decide how to complete their task.

Littered on each stage are obstacles ranging from speed-up and slow-down pads to reset buttons and more ominous impediments such as moving cars or swinging sugar packets. As with most puzzle-oriented titles, combos play a vital role in achieving high scores. Setting off a series of dominoes that finish on top of flashing blocks, for example, earns players bonus points. Switches emblazoned with the face of a particular family member can also be triggered for points, which results in a brief cut-scene depicting the humorous consequences of Mr. Domino's actions (such as the father being hit by a spring-loaded boxing glove).